Society of Diabetic Nephropathy Prevention Annals of Research in Antioxidants 2476-5511 1 1 2016 01 30 The anticancer mechanism of capsaicin on various cancer cell lines e06 e06 EN Sadaf Moghadaszadeh-Ardebili REVIEW 2015 10 13 2015 11 07 It is believed that capsaicin has tumor suppressive effects and this material induces apoptosis in various cancer cell lines such as human KB cancer cells, colorectal cancer cells, human osteosarcoma cancer cells and pancreatic cancer cells. The mechanism of anticancer effects was demonstrated by various techniques such as SRB assay, MTT assay, TUNEL assay, western blot analysis and flow cytometric analysis. These studies investigated whether treatment of capsaicin in a dose dependent manner would induce extrinsic and intrinsic pathway of programmed cell death. Capsaicin stimulates arrest of cell cycle at G2/M section and caused apoptosis in human KB cancer cells. Capsaicin has strong tumor suppressive effect. This material induces apoptosis in various cancer cell lines. The mechanism of anticancer effects was detected in both extrinsic and intrinsic pathway of programmed cell death by many cellular and molecular techniques.