Society of Diabetic Nephropathy Prevention Annals of Research in Antioxidants 2476-5511 2 2 2017 04 08 An update on ellagic acid as a natural powerful flavonoid e02 e02 EN Samaneh Khodadadi Hamid Nasri REVIEW 2017 03 12 2017 04 01 Ellagic acid is a polyphenol compound present in many fruits, nuts, and seeds, such as pomegranates, black raspberries, raspberries, strawberries, walnuts, and almonds. Some studies in the past indicated that ellagic acid showed powerful free radical scavenging action, and also has anti-diabetic, chemoprotective, anti-apoptotic, anti-inflammatory and anti-tumorigenic properties. While ellagic acid and its complex derivatives such as ellagitannins (ETs) play an important role in human nutrition and endowed with numerous biological properties, thus this substance may be suitable as a defensive factor against free radicals. Hence the aim of this paper is to review current research into the therapeutic potential of ellagic acid in prevention and treatment of some chronic conditions such as cancers or various chronic disease due to its main role as a potent scavenger of oxygen species.