Society of Diabetic Nephropathy Prevention Annals of Research in Antioxidants 2476-5511 1 2 2016 05 29 Trends toward amelioration of cisplatin nephrotoxicity e18 e18 EN Hamid Nasri Journal Article 2015 12 28 2016 01 13 Cisplatin is an antineoplastic substance extensively administered in chemotherapy of various cancers like ovarian, lung, bladder, breast, head and neck, and testicular malignancies. Conversely, its clinical application was significantly restricted due to unanticipated and very severe nephrotoxicity. Additionally effective cancer chemotherapy with this agent has been further complicated by the lack of information regarding the manner of action and factors responsible for provoking the anticancer activity. Studies regarding the side effects of cisplatin, showed acute and cumulative nephrotoxicity associated with morphological injury, has been detected in both animal and human investigations.