The anticancer mechanism of capsaicin on various cancer cell lines

Abstract

It is believed that capsaicin has tumor suppressive effects and this material induces apoptosis in various cancer cell lines such as human KB cancer cells, colorectal cancer cells, human osteosarcoma cancer cells and pancreatic cancer cells. The mechanism of anticancer effects was demonstrated by various techniques such as SRB assay, MTT assay, TUNEL assay, western blot analysis and flow cytometric analysis. These studies investigated whether treatment of capsaicin in a dose dependent manner would induce extrinsic and intrinsic pathway of programmed cell death. Capsaicin stimulates arrest of cell cycle at G2/M section and caused apoptosis in human KB cancer cells. Capsaicin has strong tumor suppressive effect. This material induces apoptosis in various cancer cell lines. The mechanism of anticancer effects was detected in both extrinsic and intrinsic pathway of programmed cell death by many cellular and molecular techniques.

Keywords: Capsaicin, Apoptosis, Cancer cell line, Antioxidant, Cancer, Colorectal cancer, Reactive oxygen species