Ann Res Antioxid. 2017;2(2): e03.
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  PDF Download: 6

Original Article

Effect of gallic acid on liver oxidative stress markers in renal ischemia-reperfusion injury in rats

Hassan Ahmadvand 1,2, Esmaeel Babaeenezhad 3*, Forouzan Hadipour Moradi 4, Ahmad Cheraghi Venool 5

1 Razi Herbal Researches Center, Lorestan University of Medical Sciences, Khorramabad, Iran
2 Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
3 Student of Veterinary Medicine, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran
4 Department of Biochemistry, Payame Noor University, Isfahan, Iran
5 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
*Corresponding Author: Esmaeel Babaeenezhad, Email: es.babaeenezhad1391@gmail.com

Abstract

Introduction: Renal ischemia-reperfusion (RIR) is one of the reasons of acute renal failure (ARF). Furthermore, RIR induces oxidative stress in the liver.

Objectives: Considering the role of gallic acid (GA) as an antioxidant, we used GA to investigate its effect on liver oxidative stress markers in RIR injury in rats.

Materials and Methods: Twenty-two adult male Sprague-Dawley rats were randomly divided into 3 groups; group I (control; non-ischemic animals, n = 8), group II (renal I/R injury, n = 7) and group III (renal I/R injury + GA 100 mg/kg i.p daily, n = 7). Pedicles were occluded for 45 minutes (ischemia) and subjected to 24 hours of reperfusion. Daily pretreatment began 15 days before the induction of RIR. Hepatic malondialdehyde (MDA) and glutathione (GSH) were determined, and catalase (CAT) and glutathione peroxidase (GPX) activities in the liver were assessed.

Results: The level of MDA in the liver significantly decreased in treated RIR rats compared with the untreated group. The level of GSH in the liver increased in treated RIR rats compared with the untreated group. CAT and GPX activities in the liver were significantly less in the untreated group than the control one. GA significantly increased CAT and GPX activities in the liver of the treated group.

Conclusion: Our study showed that the pretreatment with GA as an antioxidant agent has protective effects on liver oxidative stress markers in RIR injury in rats.


Citation: Ahmadvand H, Babaeenezhad E, Hadipour-Moradi F, Cheraghi-Venool A. Effect of gallic acid on liver oxidative stress markers in renal ischemiareperfusion injury in rats. Ann Res Antioxid. 2017;2(1):e03.
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Submitted: 07 Jan 2017
Accepted: 23 Mar 2017
ePublished: 08 Apr 2017
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