Abstract
Diabetic nephropathy (DN) or diabetic kidney disease (DKD) is a serious complication of diabetes. Various mechanisms were suggested for the development of DKD. The high production of reactive oxygen species (ROS) is the central and major mediator of diabetes tissue damage. Some studies showed disruption of normal gut microbiota (dysbiosis) associated with systemic and metabolic disease, such as chronic kidney disease. Other studies also demonstrated the correlation between oxidative stress and misbalance of gut bacteria and suggested the consumption of probiotics in diabetic patients. This paper will review the research conducted on the effect of probiotic soy milk on DN.